基于細(xì)胞的研究背后有許多驅(qū)動因素，包括組織工程、體外毒理學(xué)、藥物遞送以及抗菌涂層。

表面等離子共振分析儀最初用于蛋白質(zhì)相互作用的測量。直到最近，研究人員才開始開發(fā)SPR用于測量活體細(xì)胞。我們很自豪成為第一家能夠測量跨細(xì)胞和細(xì)胞旁攝取的SPR制造商。
BioNavis和赫爾辛基大學(xué)一起開創(chuàng)了藥物和納米粒子-細(xì)胞相互作用的測量。我們的許多用戶使用MP-SPR測量細(xì)胞在不同生物材料和涂層上的擴(kuò)散和附著。MP-SPR還可用作檢測細(xì)胞特定代謝產(chǎn)物的生物傳感器，以確認(rèn)細(xì)胞分化和/或細(xì)胞功能。同樣，一些小組正在研究生物膜的形成或抗菌涂料。

選擇MP-SPR用于活細(xì)胞的五個原因：

1、能夠?qū)崟r測量活細(xì)胞和細(xì)菌附著

2、能夠無標(biāo)記區(qū)分滲透和內(nèi)化
3、表面自由度
4、溫度和剪應(yīng)力控制
5、MP-SPR與電化學(xué)的結(jié)合

MP-SPR可以回答的關(guān)于活細(xì)胞的五個關(guān)鍵問題：

1、這種藥物的藥物吸收途徑是什么？
2、哪種納米粒子最適合藥物輸送？
3、納米粒子或病毒是如何進(jìn)入細(xì)胞的？
4、細(xì)胞附著在表面的動力學(xué)是多少？
5、哪種表面對細(xì)菌生長最具抵抗力？

BioNavis_AN#137_使用MP-SPR測量藥物與細(xì)胞單層的相互作用

BioNavis_AN#145_使用MP-SPR研究病毒之間的相互作用

BioNavis_AN#154_使用MP-SPR測量植入材料表面癌細(xì)胞的實時檢測與粘附

BioNavis_AN#156_用MP-SPR測量細(xì)胞對納米顆粒的攝入

BioNavis_AN#160_生物傳感器用于檢測奶粉中的細(xì)菌

Selected publications:

• Endothelial cells' biophysical, biochemical, and chromosomal aberrancies in high ‐ glucose condition within the diabetic range, Cell Biochemistry & Function, 2017, p. 1-15
• Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier, PLoS ONE 11(8): e0160705, 2016
• Real-Time Label-Free Monitoring of Nanoparticle Cell Uptake, Small, 2016
• Real-Time Protein and Cell Binding Measurements on Hydroxyapatite Coatings, J. of Functional Biomaterials, 2016, Vol. 7(3), p. 23
• Elucidating the Signal Responses of Multi-Parametric Surface Plasmon Resonance Living Cell Sensing: A Comparison between Optical Modeling and Drug–MDCKII Cell Interaction Measurements, PLoS ONE 8(8), 2013, e72192
• Biomimetic collagen I and IV double layer Langmuir–Schaefer films as microenvironment for human pluripotent stem cell derived retinal pigment epithelial cells, Biomaterials, Volume 1, May 2015, Pages 257-269
• Structural and Viscoelastic Properties of Layer-by-Layer Extracellular Matrix (ECM) Nanofilms and Their Interactions with Living Cell, ACS Biomater. Sci. Engineering, 2015, 1[9]: p. 816–824
• Microbial attachment and adsorption–desorption kinetic of tightly bound extracellular polymeric substances on model organic surfaces, Chemical Engineering Journal, 2015, 279: p. 516–521
• Investigation of cell behaviors on thermo-responsive PNIPAM microgel films, Colloids and Surfaces B: Biointerfaces, 132: p. 202–207
• Biofunctionalization of titanium surface with multilayer films modified by heparin-VEGF-fibronectin complex to improve endothelial cell proliferation and blood compatibility,  J. of Biomed. Mat. Research Part A, 2013, 101A, 413–420
• Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the anti-tumor immunity and efficacy against melanoma, Capasso et al., Taylor & Francis Online, 2015